Desmopressin is a vasopressin (antidiuretic hormone) analog that has some interesting and varied applications. It also comes as an oral, injectable, or intranasal formulation.
- Treatment of bleeding disorders (von Willebrand disease and uremic bleeding are the most common, I think)
- Treatment of SIADH (it’s important to note that desmopressin doesn’t actually lower the sodium, it is given prophylactically or reactively to prevent overcorrection of sodium in hyponatremia. In fact, when desmopressin is given for DI, hyponatremia is a potential adverse effect!)
- Treatment of diabetes insipidus (ONLY for central DI, since in nephrogenic DI the kidneys are resistant to ADH)
- Treatment of nocturnal eneuresis (bed wetting)