Hiccups can be extremely annoying, and when they last for hours or days, torture. So what are some strategies to treat them?
In a 2015 systematic review of pharmacologic therapy for persistent/intractable hiccups in 341 patients in 15 studies, Steger et al noted that treatment of the underlying condition was the most successful, but there were no high-quality data to allow for pharmacologic treatment recommendations.
- Chlorpromazine (Compazine): drug of choice in many situations.
- Baclofen: can be used in patients with renal impairment
- Gabapentin: possibly more effective in patients with CNS lesions
- Metaclopramide (Reglan)
- HaldolL reported effective in doses 2-5 mg IV
- Lidocaine: there is very limited evidence, such as small case series in cancer patients
- Ketamine: again, very limited evidence